Nonmyeloablative allogeneic stem cell transplantation (NST) for lymphoid malignancies using pentostatin/low-dose total body irradiation
نویسندگان
چکیده
منابع مشابه
Nonmyeloablative allogeneic hematopoietic stem cell transplantation.
Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patient...
متن کاملCMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath.
We would like to comment on the recent report by Chakrabarti et al 1 on the risk of cytomegalovirus (CMV) infection following nonmyeloablative allogeneic transplantation. The conditioning regimen utilized by the authors consisted of fludarabine, melpha-lan, and a total dose of 100 mg of alemtuzumab (Campath-1H) given over 5 days. They found an 84.3% probability of CMV infection in patients at h...
متن کاملNonmyeloablative allogeneic stem cell transplantation using alternative donors.
BACKGROUND The reduced intensity of nonmyeloablative stem cell transplant (NMSCT) has enabled older patients to benefit from allogeneic therapy. Identification of suitable donors remains an obstacle. The use of alternative donors for stem cell therapy is essential to ensure broad applicability of allogeneic therapy. METHODS Clinical results using alternative hematopoietic stem cell donors are...
متن کاملNonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic review.
BACKGROUND Increasingly, clinicians advocate the use of nonmyeloablative allogeneic stem-cell transplants (NM-allo-SCTs, "mini-transplants") to manage hematologic malignancies. They hypothesize that NM-allo-SCT is equally efficacious to standard allo-SCT but produces less regimen-related toxicity. METHODS To analyze available evidence on the benefits and harms of "mini-transplants," we identi...
متن کاملNonmyeloablative allogeneic stem cell transplantation for nasopharyngeal carcinoma.
We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow-an effect likely achieved via a graft-versus-tumor respons...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2004
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2003.12.109